Andy Trevelyan, Newcastle organised a wonderful meeting on chloride regulation, inhibitory function and neurological diseases. 

Abstract:

Fast synaptic inhibition is provided mainly by chloride conducting GABAergic and glycinergic receptors, and consequently is influenced hugely bythe relative levels of chloride inside and outside neurons. Intraneuronal chloride levels can vary widely, both physiologically and in disease. We will discuss how this happens and how it is regulated, how we can image chloride levels and manipulate them optogenetically, and how chloride dysregulation can give rise to different neurological conditions.

K. Kaila (Finland)

Arginine vasopressin suppresses perinatal neuronal network events driven by depolarizing GABA: implications on acute and long-term protection of the brain

G. Ratto (Italy)

Imaging of intracellular Chloride in vivo by means of 2-photon in vivo spectroscopy

A. Trevelyan (Newcastle, United Kingdom)

Using optogenetic manipulation of intraneuronal Cl to influence epileptic activity.

L. Cancedda (Italy)

Modulation of Intracellular Chloride Concentration to Regulate Synaptic Plasticity and Rescue Cognitive Functions in Down Syndrome