Unconventional NMDA Receptor Signalling at Central Synapses 

In the classical view, postsynaptic NMDA receptors (NMDARs) act via calcium to signal coincidence detection in Hebbian learning. However, growing evidence shows that NMDARs can signal metabotropically, without the need for calcium influx. Moreover, NMDARs have been found presynaptically, where they do not act as classical Hebbian coincidence detectors. In this talk, I will highlight novel findings indicating how the NMDAR field has expanded to include unconventional modes of NMDAR action including independent control differential regulation of evoked and spontaneous neurotransmitter release. 

Jesper Sjöström

Associate Professor

McGill University

UZH-Irchel, lecture hall Y55 H12, Winterthurerstrasse 190, 8057 Zurich

Friday, 16.03.18, 11:30 – 12:30